Efficient Microarray Data Classification with Three-Stage Dimensionality Reduction

Rasmita Dash, B. B. Misra, Satchidananda Dehuri, Sung Bae Cho

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)


High dimensionality and small sample size are the intrinsic nature of microarray data, which require effective computational methods to discover useful knowledge from it. Classification of microarray data is one of the important tasks in this field of work. Representation of the search space with thousands of genes makes this work much complex and difficult to classify efficiently. In this work, three different stages have been adopted to handle the crush of dimensionality and classify the microarray data. At the first stage, statistical measures are used to remove genes that do not contribute for classification. In the second stage, more noisy genes are removed by considering signal-to-noise ratio (SNR). In the third stage, principal component analysis (PCA) method is used to further reduce the dimension. Finally, these reduced datasets are presented to different classification techniques to evaluate their performance. Here, four different classification algorithms are used such as artificial neural network (ANN), naïve Bayesian classifier, multiple linear regression (MLR), and k-nearest neighbor (k-NN) to validate the benefits of three-stage dimensionality reduction. The experimental results show that the use of statistical methods, SNR, and PCA improves the overall performance of the classifiers.

Original languageEnglish
Title of host publicationIntelligent Computing, Communication and Devices - Proceedings of ICCD 2014
PublisherSpringer Verlag
Number of pages8
EditionVOLUME 1
ISBN (Print)9788132220114
Publication statusPublished - 2015
Event1st International Conference on Intelligent Computing, Communication and Devices, ICCD 2014 - Bhubaneswar, India
Duration: 2014 Apr 182014 Apr 19

Publication series

NameAdvances in Intelligent Systems and Computing
NumberVOLUME 1
Volume308 AISC
ISSN (Print)2194-5357


Other1st International Conference on Intelligent Computing, Communication and Devices, ICCD 2014

Bibliographical note

Funding Information:
The authors gratefully acknowledge the support of the Original Technology Research Program for Brain Science through the National Research Foundation (NRF) of Korea (NRF:2010-0018948) funded by the Ministry of Education, Science, and Technology.

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Computer Science(all)


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