Efficacy of Rhino-Protect ointment after endoscopic sinus surgery: a prospective, randomized, multicenter study

Kyu Sup Cho, Soo Whan Kim, Jin Kook Kim, Chang Hoon Kim

Research output: Contribution to journalArticlepeer-review


Objective: Blocking airflow into the sinonasal cavity after surgery may help to keep the cavity moist and thus decrease postoperative crusting. Here we investigated the efficacy of Rhino-Protect ointment following endoscopic sinus surgery (ESS). Subjects and methods: A total of 93 patients with chronic rhinosinusitis who underwent identical ESS were enrolled. After surgery, all patients were instructed to perform nasal saline irrigation and deliver a nasal spray to each nostril, then to apply Rhino-Protect ointment to one nostril only; the other nostril served as a control. Subjective symptoms, postoperative Lund–Kennedy (LK) endoscopic scores, and adverse reactions 14 and 28 days after treatment were evaluated. Results: The Rhino-Protect ointment significantly reduced pain (p = 0.015 at 28 days), dryness (p = 0.009 at 14 days and p = 0.045 at 28 days), and crusting (p = 0.047 at 14 days), and was associated with significantly lower LK scores 14 and 28 days after treatment (p = 0.037 and p = 0.007, respectively). Statistically significant differences were noted in the LK edema subscore at 14 days (p = 0.043) and in LK crusting subscores at 14 and 28 days (p = 0.005 and p = 0.006, respectively). No patient reported any serious adverse event associated with Rhino-Protect use. Conclusion: Applying Rhino-Protect after ESS significantly reduced the formation of edema and crusts, leading to improving the patients’ discomfort for pain, dryness, and crust.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalEuropean Archives of Oto-Rhino-Laryngology
Issue number1
Publication statusPublished - 2021 Jan

Bibliographical note

Funding Information:
This work was financially supported by Hanwha Pharma Co., Ltd. (Seoul, South Korea) and Dr. Theiss Naturwaren GmbH (Homburg, Germany).

Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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