Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

Ji Young Kim, Jean Kyung Paik, Oh Yoen Kim, Hae Won Park, Jin Hee Lee, Yangsoo Jang, Jong Ho Lee

Research output: Contribution to journalArticlepeer-review

142 Citations (Scopus)


Objective: The objective was to determine the effects of lycopene supplementation on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) and oxidative stress. Methods: Healthy men (n= 126) were randomized to receive placebo (n= 38), 6. mg (n= 41), or 15. mg (n= 37) lycopene daily for 8-week. Results: Serum lycopene increased in a dose-dependent manner after 8-week supplementation (P< 0.001). The 15. mg/day group had greater increase in plasma SOD activity (P= 0.014) and reduction in lymphocyte DNA comet tail length (P= 0.042) than the placebo group. Intragroup comparison revealed a 23% increase in RH-PAT index from baseline (1.45 ± 0.09 vs. 1.79 ± 0.12; P= 0.032) in the 15. mg/day group after 8-week. hs-CRP, systolic blood pressure, sICAM-1 and sVCAM-1 significantly decreased, and β-carotene and LDL-particle size significantly increased only in the 15. mg/day group. Interestingly, the beneficial effect of lycopene supplementation on endothelial function (i.e., RH-PAT and sVCAM-1) were remarkable in subjects with relatively impaired endothelial cell function at initial level. Changes in RH-PAT index correlated with SOD activity (r= 0.234, P= 0.017) especially in the 15. mg lycopene/day group (r= 0.485, P= 0.003), lymphocyte DNA comet tail moment (r= -0.318, P= 0.001), and hs-CRP (r= -0.238, P= 0.011). In addition, changes in lycopene correlated with hs-CRP (r= -0.230, P= 0.016) and SOD activity (r= 0.205, P= 0.037). Conclusion: An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function.

Original languageEnglish
Pages (from-to)189-195
Number of pages7
Issue number1
Publication statusPublished - 2011 Mar

Bibliographical note

Funding Information:
Financial support: National Research Foundation, Ministry of Education, Science and Technology ( 2010-0015017 , M10642120002-06N4212-00210 , and 2008-359-C00050 ) and Korea Health 21 R&D Projects, Ministry of Health & Welfare ( A080348 ), Seoul, Korea.

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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