TY - JOUR
T1 - Effects of collagen tripeptide supplement on photoaging and epidermal skin barrier in UVB-exposed hairless mice
AU - Pyun, Hee Bong
AU - Kim, Minji
AU - Park, Jieun
AU - Sakai, Yasuo
AU - Numata, Noriaki
AU - Shin, Jin Yeong
AU - Shin, Hyun Jung
AU - Kim, Do Un
AU - Hwang, Jae Kwan
PY - 2012
Y1 - 2012
N2 - Collagen tripeptide (CTP) is a functional food material with several biological effects such as improving dry skin and wound and bone fracture healing. This study focused on the anti-photoaging effects of CTP on a hairless mouse model. To evaluate the effects of CTP on UVB-induced skin wrinkle formation in vivo, the hairless mice were exposed to UVB radiation with oral administration of CTP for 14 weeks. Compared with the untreated UVB control group, mice treated with CTP showed significantly reduced wrinkle formation, skin thickening, and transepidermal water loss (TEWL). Skin hydration and hydroxyproline were increased in the CTP-treated group. Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and -9 expressions. Oral administration of CTP increased skin elasticity and decreased abnormal elastic fiber formation. Erythema was also decreased in the CTP-treated group. Taken together, these results strongly suggest that CTP has potential as an anti-photoaging agent.
AB - Collagen tripeptide (CTP) is a functional food material with several biological effects such as improving dry skin and wound and bone fracture healing. This study focused on the anti-photoaging effects of CTP on a hairless mouse model. To evaluate the effects of CTP on UVB-induced skin wrinkle formation in vivo, the hairless mice were exposed to UVB radiation with oral administration of CTP for 14 weeks. Compared with the untreated UVB control group, mice treated with CTP showed significantly reduced wrinkle formation, skin thickening, and transepidermal water loss (TEWL). Skin hydration and hydroxyproline were increased in the CTP-treated group. Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and -9 expressions. Oral administration of CTP increased skin elasticity and decreased abnormal elastic fiber formation. Erythema was also decreased in the CTP-treated group. Taken together, these results strongly suggest that CTP has potential as an anti-photoaging agent.
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U2 - 10.3746/pnf.2012.17.4.245
DO - 10.3746/pnf.2012.17.4.245
M3 - Article
AN - SCOPUS:84873140973
SN - 2287-1098
VL - 17
SP - 245
EP - 253
JO - Preventive Nutrition and Food Science
JF - Preventive Nutrition and Food Science
IS - 4
ER -