Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis

Seo Hyun Kim; Hana Lee; Dong Hyun Hwang; Dong Hyun Seo; Han Sung Kim; Seungkwan Cho

doi:10.1109/EMBSISC.2016.7508615

Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis

Seo Hyun Kim, Hana Lee, Dong Hyun Hwang, Dong Hyun Seo, Han Sung Kim, Seungkwan Cho

Division of Medical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.

Original language	English
Title of host publication	2016 IEEE EMBS International Student Conference
Subtitle of host publication	Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781509009350
DOIs	https://doi.org/10.1109/EMBSISC.2016.7508615
Publication status	Published - 2016 Jul 8
Event	2016 IEEE EMBS International Student Conference, ISC 2016 - Ottawa, Canada Duration: 2016 May 29 → 2016 May 31

Publication series

Name	2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings

Other

Other	2016 IEEE EMBS International Student Conference, ISC 2016
Country/Territory	Canada
City	Ottawa
Period	16/5/29 → 16/5/31

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

All Science Journal Classification (ASJC) codes

Biotechnology
Genetics
Health(social science)
Biomedical Engineering

Access to Document

10.1109/EMBSISC.2016.7508615

Cite this

Kim, S. H., Lee, H., Hwang, D. H., Seo, D. H., Kim, H. S., & Cho, S. (2016). Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. In 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings [7508615] (2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBSISC.2016.7508615

Kim, Seo Hyun ; Lee, Hana ; Hwang, Dong Hyun et al. / Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. (2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings).

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title = "Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis",

abstract = "Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.",

author = "Kim, {Seo Hyun} and Hana Lee and Hwang, {Dong Hyun} and Seo, {Dong Hyun} and Kim, {Han Sung} and Seungkwan Cho",

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Kim, SH, Lee, H, Hwang, DH, Seo, DH, Kim, HS & Cho, S 2016, Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. in 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings., 7508615, 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings, Institute of Electrical and Electronics Engineers Inc., 2016 IEEE EMBS International Student Conference, ISC 2016, Ottawa, Canada, 16/5/29. https://doi.org/10.1109/EMBSISC.2016.7508615

Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. / Kim, Seo Hyun; Lee, Hana; Hwang, Dong Hyun et al.
2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. 7508615 (2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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N2 - Induction of micro-current in subject is known to be effective on the treatment of inflammatory disease. Thus, this study evaluated that the micro-current electrical treatment (MET) can reduce rheumatoid arthritis (RA), which is one of inflammatory disease, and tried to find optimized level of current for treatment. 55 male 11-week-old C57BL/6 mice were used and randomly allocated into five groups; normal group (N; n=11), the group of induced RA (C; n=11) and three groups of induced RA with MET (M) using different levels of current by 22 μA, 50 μA, and 400 μA (22M, 50M and 400M; n=11, respectively). MET was carried out for 1 hour each day. Both 3rd metatarsal (3rd MT) and tarsal (T) were scanned by in-vivo micro computed tomography (micro-CT) at 0week and after 3weeks in order to obtain structural parameters including BMD (Bone mineral density), BV (Bone volume) and Obj.N (Mean number of objects per slice). In M groups, all the measured parameters after 3 weeks were significantly higher than those of C group regardless of the current levels. However, there is no significant difference among the different levels of electrical current at 3week. These results indicated that the MET may be effective on the treatment of RA. However, we cannot assure the optimized level of current to treat RA tremendously.

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Kim SH, Lee H, Hwang DH, Seo DH, Kim HS, Cho S. Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis. In 2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2016. 7508615. (2016 IEEE EMBS International Student Conference: Expanding the Boundaries of Biomedical Engineering and Healthcare, ISC 2016 - Proceedings). doi: 10.1109/EMBSISC.2016.7508615

Effectiveness of micro-current electrical stimulation for treating rheumatoid arthritis

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