TY - JOUR
T1 - Effect of subthalamic nucleus lesions in a 6-hydroxydopamine-induced rat parkinsonian model
T2 - Behavioral and biochemical studies
AU - Hwang, Yong Sup
AU - Shim, Insop
AU - Lee, Bom Bee
AU - Chang, Jin Woo
PY - 2006
Y1 - 2006
N2 - Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.
AB - Object. The purpose of this study was to determine whether subthalamic nucleus (STN) ablation caused by kainic acid can restore dopaminergic neurotransmission and improve motor deficits in a 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian model. Methods. The authors investigated behavioral changes in rats displaying parkinsonian symptoms (6-OHDA-lesioned rats) after an STN lesion was created using kainic acid. They also measured levels of dopamine and its metabolites following tissue dissection. The results of this study showed that STN ablation led to behavioral improvement in parkinsonian motor deficits. Increased levels of dopamine were also observed in the striatum and globus pallidus externus (GPE). Conclusions. The results indicate that creation of an STN lesion in this hemiparkinsonian rat model may counteract some of the neurochemical changes within the striatum and GPE caused by the 6-OHDA, and influence striatal dopaminergic metabolism.
UR - http://www.scopus.com/inward/record.url?scp=33747283139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747283139&partnerID=8YFLogxK
U2 - 10.3171/jns.2006.105.2.284
DO - 10.3171/jns.2006.105.2.284
M3 - Article
C2 - 17219835
AN - SCOPUS:33747283139
SN - 0022-3085
VL - 105
SP - 284
EP - 287
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
IS - 2
ER -