Effect of primate bone marrow stromal cells on survival and neurite outgrowth

Keung Nyun Kim; James D. Guest; Jin Soo Oh; William A. Pennant; Do Heum Yoon; Yoon Ha

doi:10.1097/WNR.0b013e32833da3a6

Effect of primate bone marrow stromal cells on survival and neurite outgrowth

Keung Nyun Kim, James D. Guest, Jin Soo Oh, William A. Pennant, Do Heum Yoon, Yoon Ha

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We tested whether bone marrow stromal cells (BMSCs) could enhance the survival and neurite growth of dorsal root ganglia (DRG) through substrate effects or secreted factors. Our results showed that in DRG with BMSCs and BMSC-conditioned media cultures compared with DRG-fibroblast cultures, there was a significant increase in the number and length of, area covered by, and number of cells with definite neurites. In cytokine assays with conditioned media, vascular endothelial growth factor, granulocyte macrophage colony-stimulating factor, and IL-6 secreted by BMSCs may contribute to observed neurotrophic effects. These findings indicate that BMSCs of adult Macaca fascicularis increased neuronal survival and promoted neurite outgrowth of DRG by means of secretory factors.

Original language	English
Pages (from-to)	877-881
Number of pages	5
Journal	NeuroReport
Volume	21
Issue number	13
DOIs	https://doi.org/10.1097/WNR.0b013e32833da3a6
Publication status	Published - 2010 Sept 15

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1097/WNR.0b013e32833da3a6

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abstract = "We tested whether bone marrow stromal cells (BMSCs) could enhance the survival and neurite growth of dorsal root ganglia (DRG) through substrate effects or secreted factors. Our results showed that in DRG with BMSCs and BMSC-conditioned media cultures compared with DRG-fibroblast cultures, there was a significant increase in the number and length of, area covered by, and number of cells with definite neurites. In cytokine assays with conditioned media, vascular endothelial growth factor, granulocyte macrophage colony-stimulating factor, and IL-6 secreted by BMSCs may contribute to observed neurotrophic effects. These findings indicate that BMSCs of adult Macaca fascicularis increased neuronal survival and promoted neurite outgrowth of DRG by means of secretory factors.",

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AU - Kim, Keung Nyun

AU - Guest, James D.

AU - Oh, Jin Soo

AU - Pennant, William A.

AU - Yoon, Do Heum

AU - Ha, Yoon

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Effect of primate bone marrow stromal cells on survival and neurite outgrowth

Abstract

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