Abstract
Controlled release formations of drugs were prepared with matrix materials of the natural polysaccharides sodium alginate and L-carrageenan. The drugs used were sodium salicylate (anionic) and lidocaine-HCl (cationic). The release characteristics of the drugs were studied under different pH and compositions of aqueous media. The cationic drug (lidocaine-HCl) was released more slowly than the anionic one (sodium salicylate) because of the negative charge of the matrices. The release from both sodium alginate and L- carrageenan tablet was retarded in acidic medium. At the same pH of the medium, the release into buffer solutions (containing metallic cations Na+ and K+, respectively) was slower than into HCl solution.
Original language | English |
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Pages (from-to) | 13-18 |
Number of pages | 6 |
Journal | Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents |
Volume | 5 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1998 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science