Effect of particle size on new bone formation in vivo using calcium phopshate glass

Hyun Ju Moon; Racquel Z. LeGeros; Kyoung Nam Kim; Kwang Mahn Kim; Seong Ho Choi; Chong Kwan Kim; Yong Keun Lee

doi:10.4028/0-87849-422-7.165

Effect of particle size on new bone formation in vivo using calcium phopshate glass

Hyun Ju Moon, Racquel Z. LeGeros, Kyoung Nam Kim, Kwang Mahn Kim, Seong Ho Choi, Chong Kwan Kim, Yong Keun Lee

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF₂-P₂O₅-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Key Engineering Materials
Volume	330-332 I
DOIs	https://doi.org/10.4028/0-87849-422-7.165
Publication status	Published - 2007

All Science Journal Classification (ASJC) codes

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.4028/0-87849-422-7.165

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title = "Effect of particle size on new bone formation in vivo using calcium phopshate glass",

abstract = "The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.",

author = "Moon, {Hyun Ju} and LeGeros, {Racquel Z.} and Kim, {Kyoung Nam} and Kim, {Kwang Mahn} and Choi, {Seong Ho} and Kim, {Chong Kwan} and Lee, {Yong Keun}",

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AU - Moon, Hyun Ju

AU - LeGeros, Racquel Z.

AU - Kim, Kyoung Nam

AU - Kim, Kwang Mahn

AU - Choi, Seong Ho

AU - Kim, Chong Kwan

AU - Lee, Yong Keun

PY - 2007

Y1 - 2007

N2 - The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

AB - The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

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JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Effect of particle size on new bone formation in vivo using calcium phopshate glass

Abstract

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