Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Ki Yong Lee; Lim Hwang; Eun Ju Jeong; Seung Hyun Kim; Young Choong Kim; Sang Hyun Sung

doi:10.1271/bbb.100200

Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Ki Yong Lee, Lim Hwang, Eun Ju Jeong, Seung Hyun Kim, Young Choong Kim, Sang Hyun Sung

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.

Original language	English
Pages (from-to)	1704-1706
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	8
DOIs	https://doi.org/10.1271/bbb.100200
Publication status	Published - 2010

Bibliographical note

Funding Information:
We thank Biokorea Co., Seoul, Korea for providing the herbs of A. eupatoria. This study was financially supported by Amorepacific Corporation R&D Center, Yongin, Korea.

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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title = "Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells",

abstract = "A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.",

author = "Lee, {Ki Yong} and Lim Hwang and Jeong, {Eun Ju} and Kim, {Seung Hyun} and Kim, {Young Choong} and Sung, {Sang Hyun}",

note = "Funding Information: We thank Biokorea Co., Seoul, Korea for providing the herbs of A. eupatoria. This study was financially supported by Amorepacific Corporation R&D Center, Yongin, Korea.",

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doi = "10.1271/bbb.100200",

language = "English",

volume = "74",

pages = "1704--1706",

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AU - Lee, Ki Yong

AU - Hwang, Lim

AU - Jeong, Eun Ju

AU - Kim, Seung Hyun

AU - Kim, Young Choong

AU - Sung, Sang Hyun

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Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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