A methanolic extract of Agrimonia eupatoria (Rosaceae) significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-β-D-(2″-O-acetyl- 6″-(E)-p-coumaroyl)-glucopyranoside (2″-acetyltiliroside (1), was isolated from the methanolic extract of A. eupatoria stems together with nine known flavonoids. Compounds 4, 7, 8 and 9 all showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells.
Bibliographical noteFunding Information:
We thank Biokorea Co., Seoul, Korea for providing the herbs of A. eupatoria. This study was financially supported by Amorepacific Corporation R&D Center, Yongin, Korea.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry