Abstract
The aim of the study was to investigate the effect of low doses of irradiation on the induction of an apoptotic adaptive response in the murine system using C3H/HeJ mice bearing 8 mm syngeneic tumors, HCa-I and OCa-I. In OCa-I, the 0.05 Gy priming dose significantly reduced the 25 Gy-induced apoptosis by 30%, whereas this reduction was not seen in HCa-I. The analysis of apoptosis-regulating molecules showed that the application of a priming dose increased the radiation-induced p53 level in both tumors. No other regulators changed in OCa-I. However, in HCa-I, the application of a priming dose increased radiation-induced Bcl-XL and Bcl-XS, but not Bcl-2 or Bax. An apoptotic adaptive response induced by low-dose radiation was shown in one murine tumor, OCa-I and Bcl-XL and Bcl-XS appeared to be implicated.
| Original language | English |
|---|---|
| Pages (from-to) | 335-339 |
| Number of pages | 5 |
| Journal | Radiation and Environmental Biophysics |
| Volume | 40 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2001 |
Bibliographical note
Funding Information:Acknowledgement This work was supported by the Nuclear Research and Development Program (50044-2000) from the Korean Ministry of Science and Technology.
All Science Journal Classification (ASJC) codes
- Biophysics
- Radiation
- Environmental Science(all)