Effect of ionizing radiation on rat tissue: Proteomic and biochemical analysis

Eui Chul Park, Jong Bok Yoon, Jin Sil Seong, Kyoung Soo Choi, Eung Sik Kong, Yun Jeong Kim, Young Mee Park, Eun Mi Park

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.

Original languageEnglish
Pages (from-to)19-35
Number of pages17
JournalPreparative Biochemistry and Biotechnology
Issue number1
Publication statusPublished - 2006 Feb 1

Bibliographical note

Funding Information:
This work was supported by NIH CA109480, CA111846, U.S. Army PC050127, Korea Research Foundation Grant KRF-2004-005-C00112, and University of Incheon.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry


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