Effect of an excipient on the formation of PLGA particles using supercritical fluid

In Il Jung; Seungjoo Haam; Giobin Lim; Jong Hoon Ryu

doi:10.7317/pk.2012.36.1.001

Effect of an excipient on the formation of PLGA particles using supercritical fluid

In Il Jung, Seungjoo Haam, Giobin Lim, Jong Hoon Ryu

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we employed hydroxypropyl-β-cyclodextrin (HP-β-CD) as an excipient to produce poly(lactic-co-glycolic acid) (PLGA) fine particles by a supercritical fluid process, called aerosol solvent extraction system (ASES), and investigated the effect of HP-β-CD content on the morphology of the particles. The influence of HP-β-CD on the drug release characteristics of paclitaxel-loaded PLGA particles was also evaluated. Fine particles were obtained when the HP-β-CD content in PLGA/HP-β-CD mixtures was greater than 40% and 30%, respectively, for PLGA(75:25) and PLGA(50:50), whereas a film-like precipitate was obtained for lower HP-β-CD content. The release rate for paclitaxel loaded PLGA(75:25)/HP-β-CD particles was found to increase with HP-β-CD content.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Polymer (Korea)
Volume	36
Issue number	1
DOIs	https://doi.org/10.7317/pk.2012.36.1.001
Publication status	Published - 2012 Jan

All Science Journal Classification (ASJC) codes

Chemical Engineering(all)
Polymers and Plastics
Materials Chemistry

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title = "Effect of an excipient on the formation of PLGA particles using supercritical fluid",

abstract = "In this study, we employed hydroxypropyl-β-cyclodextrin (HP-β-CD) as an excipient to produce poly(lactic-co-glycolic acid) (PLGA) fine particles by a supercritical fluid process, called aerosol solvent extraction system (ASES), and investigated the effect of HP-β-CD content on the morphology of the particles. The influence of HP-β-CD on the drug release characteristics of paclitaxel-loaded PLGA particles was also evaluated. Fine particles were obtained when the HP-β-CD content in PLGA/HP-β-CD mixtures was greater than 40% and 30%, respectively, for PLGA(75:25) and PLGA(50:50), whereas a film-like precipitate was obtained for lower HP-β-CD content. The release rate for paclitaxel loaded PLGA(75:25)/HP-β-CD particles was found to increase with HP-β-CD content.",

author = "Jung, {In Il} and Seungjoo Haam and Giobin Lim and Ryu, {Jong Hoon}",

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AU - Jung, In Il

AU - Haam, Seungjoo

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AU - Ryu, Jong Hoon

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Y1 - 2012/1

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Effect of an excipient on the formation of PLGA particles using supercritical fluid

Abstract

All Science Journal Classification (ASJC) codes

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