Effect of actin rigidity on network contractility

Donyoung Kang, Hyungsuk Lee

Research output: Contribution to journalArticlepeer-review


The actin network plays a critical role in cellular deformations. To investigate how the filamentous structure and the characteristics of actin affect the actin network contraction induced by myosin, a computational model of actomyosin network was designed. Using the developed model, we investigated the effect of actin filament rigidity on the dynamic characteristics of the actomyosin network. Particularly, by calculating local MSD as a function of time, we found that actin filament rigidity changes the response time and the mode of the actin network contraction between superdiffusion and ballistic motions. Furthermore, the critical value of the filament rigidity which increases the network contraction speed and the contraction efficiency, was found to be similar to the rigidity of the actin in vivo.

Original languageEnglish
Pages (from-to)659-662
Number of pages4
JournalTransactions of the Korean Society of Mechanical Engineers, B
Issue number11
Publication statusPublished - 2020

Bibliographical note

Publisher Copyright:
© 2020 The Korean Society of Mechanical Engineers

All Science Journal Classification (ASJC) codes

  • Mechanical Engineering


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