Abstract
The purposes of this study are to identify the predictive parameters for the development of stress-induced hyperglycemia and to investigate the glucose metabolic homeostasis in critically burned Korean subjects. We conducted a prospective cross-sectional study of adult patients with glucose management targeting fasting and postprandial blood glucose levels less than 140 and 200 mg/dL, respectively, in patients with unrecognized diabetes. Clinical and laboratory stress parameters and insulin secretory and sensitivity parameters were assessed. Stimulated C-peptide and 24-hour urinary free cortisol predicted new-onset stress diabetes requiring insulin therapy. The subjects requiring insulin therapy were leaner and more insulin sensitive than insulin-free subjects, without significance. Glycated hemoglobin, stimulated C-peptide, homeostasis model assessment of insulin resistance, and age had a significant influence on the mean daily dose of insulin. Our present data showed that Korean subjects with dysfunctional pancreatic β-cells of critical stress are prone to become stress diabetic and require more insulin to control the hyperglycemia.
Original language | English |
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Pages (from-to) | 1307-1315 |
Number of pages | 9 |
Journal | Metabolism: Clinical and Experimental |
Volume | 59 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2010 Sept |
Bibliographical note
Funding Information:This study was supported by a grant of the Korea Healthcare Technology R&D Project , Ministry for Health , Welfare & Family Affairs, Republic of Korea ( A084589 ).
All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology