Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Tyrosine Phosphorylation 90%
• Phosphorylation 54%
• Ubiquitin 36%
• Ubiquitin Ligase 36%
• Cell Death 18%
• Mutation 18%
• Ligase 18%
• Autosomal Recessive Inheritance 18%
• Regulatory Mechanism 18%
• Mammalian Cell 9%
• Binding Affinity 9%
• Proteasome 9%
• Steady State 9%
• Lysozyme 9%
• Posttranslational Modification 9%
• Dopaminergic 9%
• Screening 9%
• Protein Aggregation 9%
• Protein 9%
• Yeast Two-Hybrid Screening 9%
• Tyrosine 9%