Dual thermopile integrated microfluidic calorimeter for biochemical thermodynamics

B. S. Kwak; B. S. Kim; H. H. Cho; J. S. Park; H. I. Jung

doi:10.1007/s10404-007-0243-7

Dual thermopile integrated microfluidic calorimeter for biochemical thermodynamics

B. S. Kwak, B. S. Kim, H. H. Cho, J. S. Park, H. I. Jung

Department of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

This article presents a new design of a silicon-based microcalorimeter made with dual thermopiles and a microchannel. The dual thermopile was fabricated with chromium and copper using a microelectromechanical system (MEMS) technique, and the microchannel was made of PDMS using soft-lithography. Each thermopile consists of 26 thermocouple pairs and 50 μm wide electrodes. The total sensitivity of thermopile is 428 μV/K. The dual thermopile system enables the microcalorimeter to acquire reliable data in a rapid and convenient manner because it detects the reaction and reference temperatures simultaneously. This self-compensation allows our device to analyze a few microliters of sample solution without the need for a surrounding adiabatic vacuum.

Original language	English
Pages (from-to)	255-262
Number of pages	8
Journal	Microfluidics and Nanofluidics
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s10404-007-0243-7
Publication status	Published - 2008 Aug

Bibliographical note

Funding Information:
Acknowledgments This work was supported by Basic Research Program of the Korea Science & Engineering Foundation (Grant no. R01-2005-000-10160-0(2006)), ICBIN of Seoul R&BD program

Funding Information:
(Grant no. 10816), and National Core Research Center for Nano-medical Technology of the Korea Science & Engineering Foundation (Grant no. R15-2004-024-01001-0).

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Materials Chemistry

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10.1007/s10404-007-0243-7

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title = "Dual thermopile integrated microfluidic calorimeter for biochemical thermodynamics",

abstract = "This article presents a new design of a silicon-based microcalorimeter made with dual thermopiles and a microchannel. The dual thermopile was fabricated with chromium and copper using a microelectromechanical system (MEMS) technique, and the microchannel was made of PDMS using soft-lithography. Each thermopile consists of 26 thermocouple pairs and 50 μm wide electrodes. The total sensitivity of thermopile is 428 μV/K. The dual thermopile system enables the microcalorimeter to acquire reliable data in a rapid and convenient manner because it detects the reaction and reference temperatures simultaneously. This self-compensation allows our device to analyze a few microliters of sample solution without the need for a surrounding adiabatic vacuum.",

author = "Kwak, {B. S.} and Kim, {B. S.} and Cho, {H. H.} and Park, {J. S.} and Jung, {H. I.}",

note = "Funding Information: Acknowledgments This work was supported by Basic Research Program of the Korea Science & Engineering Foundation (Grant no. R01-2005-000-10160-0(2006)), ICBIN of Seoul R&BD program Funding Information: (Grant no. 10816), and National Core Research Center for Nano-medical Technology of the Korea Science & Engineering Foundation (Grant no. R15-2004-024-01001-0).",

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doi = "10.1007/s10404-007-0243-7",

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AU - Kwak, B. S.

AU - Kim, B. S.

AU - Cho, H. H.

AU - Park, J. S.

AU - Jung, H. I.

N1 - Funding Information: Acknowledgments This work was supported by Basic Research Program of the Korea Science & Engineering Foundation (Grant no. R01-2005-000-10160-0(2006)), ICBIN of Seoul R&BD program Funding Information: (Grant no. 10816), and National Core Research Center for Nano-medical Technology of the Korea Science & Engineering Foundation (Grant no. R15-2004-024-01001-0).

PY - 2008/8

Y1 - 2008/8

N2 - This article presents a new design of a silicon-based microcalorimeter made with dual thermopiles and a microchannel. The dual thermopile was fabricated with chromium and copper using a microelectromechanical system (MEMS) technique, and the microchannel was made of PDMS using soft-lithography. Each thermopile consists of 26 thermocouple pairs and 50 μm wide electrodes. The total sensitivity of thermopile is 428 μV/K. The dual thermopile system enables the microcalorimeter to acquire reliable data in a rapid and convenient manner because it detects the reaction and reference temperatures simultaneously. This self-compensation allows our device to analyze a few microliters of sample solution without the need for a surrounding adiabatic vacuum.

AB - This article presents a new design of a silicon-based microcalorimeter made with dual thermopiles and a microchannel. The dual thermopile was fabricated with chromium and copper using a microelectromechanical system (MEMS) technique, and the microchannel was made of PDMS using soft-lithography. Each thermopile consists of 26 thermocouple pairs and 50 μm wide electrodes. The total sensitivity of thermopile is 428 μV/K. The dual thermopile system enables the microcalorimeter to acquire reliable data in a rapid and convenient manner because it detects the reaction and reference temperatures simultaneously. This self-compensation allows our device to analyze a few microliters of sample solution without the need for a surrounding adiabatic vacuum.

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JF - Microfluidics and Nanofluidics

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Dual thermopile integrated microfluidic calorimeter for biochemical thermodynamics

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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