Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Taehyung Kim; Ha Na Hyun; Roun Heo; Keonwook Nam; Kyungjik Yang; Young Min Kim; Yoon Suk Lee; Jae Yoon An; Jae Hyung Park; Ki Young Choi; Young Hoon Roh

doi:10.1039/d0cc01848a

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Taehyung Kim, Ha Na Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, Ki Young Choi, Young Hoon Roh

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: Rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.

Original language	English
Pages (from-to)	6624-6627
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	49
DOIs	https://doi.org/10.1039/d0cc01848a
Publication status	Published - 2020 Jun 21

Bibliographical note

Publisher Copyright:
© 2020 Royal Society of Chemistry. All rights reserved.

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d0cc01848a

Cite this

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title = "Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells",

abstract = "A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: Rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.",

author = "Taehyung Kim and Hyun, {Ha Na} and Roun Heo and Keonwook Nam and Kyungjik Yang and Kim, {Young Min} and Lee, {Yoon Suk} and An, {Jae Yoon} and Park, {Jae Hyung} and Choi, {Ki Young} and Roh, {Young Hoon}",

year = "2020",

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doi = "10.1039/d0cc01848a",

language = "English",

volume = "56",

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TY - JOUR

T1 - Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

AU - Kim, Taehyung

AU - Hyun, Ha Na

AU - Heo, Roun

AU - Nam, Keonwook

AU - Yang, Kyungjik

AU - Kim, Young Min

AU - Lee, Yoon Suk

AU - An, Jae Yoon

AU - Park, Jae Hyung

AU - Choi, Ki Young

AU - Roh, Young Hoon

PY - 2020/6/21

Y1 - 2020/6/21

N2 - A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: Rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.

AB - A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: Rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.

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U2 - 10.1039/d0cc01848a

DO - 10.1039/d0cc01848a

M3 - Article

C2 - 32463029

AN - SCOPUS:85086747115

SN - 1359-7345

VL - 56

SP - 6624

EP - 6627

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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