To investigate the possibility of treating multidrug-resistant tumors with targeted chemo-photothermal treatment, we conducted invitro and invivo studies using a doxorubicin (DOX)-resistant DLD-1 cell line (DLD-1/DOX) and nude mice with human xenograft tumors, respectively. The chemo-photothermal treatment consisted of DOX-loaded-poly(lactic co-glycolic acid)-Au half-shell nanoparticles with targeting moieties of anti-death receptor-4 monoclonal antibody conjugated to the Au surface. The cells or xenografted tumors treated with nanoparticles were exposed to near infrared light for 10min, which caused an increase in temperature to 45°C. Chemo-photothermal treatment resulted in a large reduction in the rate of tumor xenograft growth on DLD-1/DOX tumor-bearing mice with a much smaller dose of DOX than conventional DOX chemotherapy. These results demonstrate that targeted chemo-photothermal treatment can provide high therapeutic efficacy and low toxicity in the treatment of multidrug-resistant tumors.
|Number of pages||11|
|Publication status||Published - 2014 Feb|
Bibliographical noteFunding Information:
This work was financially supported by MEST through the National Research Foundation (NRF) of Korea ( NRF-2012R1A4A1029061 , NRF-2011-0017611 , and NRF-2013R1A1A304009309 ), Brain Korea 21 Plus Project for Medical Sciences , Brain Korea 21 Plus Project for Physics , and MHW through the Korean Health Technology R&D Project (Grant No. A110905 )
All Science Journal Classification (ASJC) codes
- Mechanics of Materials
- Ceramics and Composites