Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Hyunsoo Chung; Hanbyoul Cho; Candice Perry; Jaekyung Song; Kris Ylaya; Heejeong Lee; Jae Hoon Kim

doi:10.3109/1354750X.2013.827742

Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Hyunsoo Chung, Hanbyoul Cho, Candice Perry, Jaekyung Song, Kris Ylaya, Heejeong Lee, Jae Hoon Kim

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR=12.19, p=0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

Original language	English
Pages (from-to)	573-579
Number of pages	7
Journal	Biomarkers
Volume	18
Issue number	7
DOIs	https://doi.org/10.3109/1354750X.2013.827742
Publication status	Published - 2013 Nov

Bibliographical note

Funding Information:
This work was supported in part by grants from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0005230, 2011-0010286, and 2011-0007146), and faculty research grants from Yonsei University College of Medicine for 2010 and 2011 (3-2010-0072 and 6-2011-0073).

Funding Information:
After gaining institutional review board approval, 123 paraffin-embedded cervical cancer, 187 cervical intraepithelial neoplasia (CIN) and 310 matched normal cervix tissues that had been resected at Gangnam Severance Hospital, Yonsei University College of Medicine between 1996 and 2010 were retrieved. Some of the paraffin blocks were provided by the Korea Gynecologic Cancer Bank through the Bio & Medical Technology Development Program of the Korea Ministry of Education, Science and Technology. All tumor tissues were histologically revised and only specimens with sufficient tumor cells were included in the tissue microarray (TMA) construction. Tumor staging was performed according to the International Federation of Gynecology and Obstetrics (FIGO) classification system.

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/1354750X.2013.827742

Cite this

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title = "Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer",

abstract = "Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR=12.19, p=0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.",

author = "Hyunsoo Chung and Hanbyoul Cho and Candice Perry and Jaekyung Song and Kris Ylaya and Heejeong Lee and Kim, {Jae Hoon}",

note = "Funding Information: This work was supported in part by grants from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0005230, 2011-0010286, and 2011-0007146), and faculty research grants from Yonsei University College of Medicine for 2010 and 2011 (3-2010-0072 and 6-2011-0073). Funding Information: After gaining institutional review board approval, 123 paraffin-embedded cervical cancer, 187 cervical intraepithelial neoplasia (CIN) and 310 matched normal cervix tissues that had been resected at Gangnam Severance Hospital, Yonsei University College of Medicine between 1996 and 2010 were retrieved. Some of the paraffin blocks were provided by the Korea Gynecologic Cancer Bank through the Bio & Medical Technology Development Program of the Korea Ministry of Education, Science and Technology. All tumor tissues were histologically revised and only specimens with sufficient tumor cells were included in the tissue microarray (TMA) construction. Tumor staging was performed according to the International Federation of Gynecology and Obstetrics (FIGO) classification system.",

year = "2013",

month = nov,

doi = "10.3109/1354750X.2013.827742",

language = "English",

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AU - Chung, Hyunsoo

AU - Cho, Hanbyoul

AU - Perry, Candice

AU - Song, Jaekyung

AU - Ylaya, Kris

AU - Lee, Heejeong

AU - Kim, Jae Hoon

N1 - Funding Information: This work was supported in part by grants from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0005230, 2011-0010286, and 2011-0007146), and faculty research grants from Yonsei University College of Medicine for 2010 and 2011 (3-2010-0072 and 6-2011-0073). Funding Information: After gaining institutional review board approval, 123 paraffin-embedded cervical cancer, 187 cervical intraepithelial neoplasia (CIN) and 310 matched normal cervix tissues that had been resected at Gangnam Severance Hospital, Yonsei University College of Medicine between 1996 and 2010 were retrieved. Some of the paraffin blocks were provided by the Korea Gynecologic Cancer Bank through the Bio & Medical Technology Development Program of the Korea Ministry of Education, Science and Technology. All tumor tissues were histologically revised and only specimens with sufficient tumor cells were included in the tissue microarray (TMA) construction. Tumor staging was performed according to the International Federation of Gynecology and Obstetrics (FIGO) classification system.

PY - 2013/11

Y1 - 2013/11

N2 - Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR=12.19, p=0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

AB - Objective: We investigated the clinical significance of ERp57 in the progression of cervical cancer. Methods: mRNA and protein expression of ERp57 in cervical neoplasias were examined. Results: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p<0.001). Low ERp57 expression was significantly associated with worse overall survival (HR=12.19, p=0.018). Conclusions: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.

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Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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