Down-regulation of phospholipase D during differentiation of mouse F9 teratocarcinoma cells

Do Sik Min, Kyung Sun Shin, Eung Guk Kim, Seung Ryul Kim, Shin Hee Yoon, Myung Suk Kim, Yang Hyeok Jo

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11 Citations (Scopus)


Phospholipase D has been recognized as playing an important role in signal transduction in many types of cells. We investigated the expression of phospholipase D during the differentiation of F9 embryonal teratocarcinoma cells. The ADP ribosylation factor-dependent phospholipase D activity, as measured by an in vitro assay, and H2O2-induced phospholipase D activity and phospholipase D protein content in whole cells were decreased during the differentiation of F9 cells induced by a combination of dibutyryl cyclic AMP and all-trans retinoic acid. In contrast, these changes were not observed when cells were induced by retinoic acid. These results suggest that down-regulation of phospholipase D protein is associated with differentiation of F9 cells to a parietal endoderm lineage. Copyright (C) 1999 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)197-200
Number of pages4
JournalFEBS Letters
Issue number3
Publication statusPublished - 1999 Jul 9

Bibliographical note

Funding Information:
A~knowledgements." This work was supported by a research Grant (HMP-98-N-1-0012) from the Good Health R and D Project and the Ministry of Health and Welfare, R.O.K.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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