Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells

Young Han Lee; He Jin Lee; Seung Jae Lee; Do Sik Min; Suk Hwan Baek; Yong Sik Kim; Sung Ho Ryu; Pann Ghill Suh

doi:10.1016/0014-5793(94)01404-O

Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells

Young Han Lee, He Jin Lee, Seung Jae Lee, Do Sik Min, Suk Hwan Baek, Yong Sik Kim, Sung Ho Ryu, Pann Ghill Suh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	FEBS Letters
Volume	358
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(94)01404-O
Publication status	Published - 1995 Jan 23

Bibliographical note

Funding Information:
Acknowledgments." This work was supported by Korea Research Foundation Grant (KOSEF-92-24-00-05)a nd Pohang University of Science & Technology, Pohang, Korea, 1994.

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(94)01404-O

Cite this

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title = "Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells",

abstract = "Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.",

author = "Lee, {Young Han} and Lee, {He Jin} and Lee, {Seung Jae} and Min, {Do Sik} and Baek, {Suk Hwan} and Kim, {Yong Sik} and Ryu, {Sung Ho} and Suh, {Pann Ghill}",

note = "Funding Information: Acknowledgments.{"} This work was supported by Korea Research Foundation Grant (KOSEF-92-24-00-05)a nd Pohang University of Science & Technology, Pohang, Korea, 1994.",

year = "1995",

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doi = "10.1016/0014-5793(94)01404-O",

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T1 - Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells

AU - Lee, Young Han

AU - Lee, He Jin

AU - Lee, Seung Jae

AU - Min, Do Sik

AU - Baek, Suk Hwan

AU - Kim, Yong Sik

AU - Ryu, Sung Ho

AU - Suh, Pann Ghill

N1 - Funding Information: Acknowledgments." This work was supported by Korea Research Foundation Grant (KOSEF-92-24-00-05)a nd Pohang University of Science & Technology, Pohang, Korea, 1994.

PY - 1995/1/23

Y1 - 1995/1/23

N2 - Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.

AB - Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.

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Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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