Down-regulation of phospholipase C-γ1 during the differentiation of U937 cells

Young Han Lee, He Jin Lee, Seung Jae Lee, Do Sik Min, Suk Hwan Baek, Yong Sik Kim, Sung Ho Ryu, Pann Ghill Suh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Phospholipase C (PLC)-γ1 and -γ2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-γ1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-γ2 were not altered. Northern blot analysis showed that the levels of PLC-γ1 and -γ2 transcripts were not changed. These results suggest that the expression of PLC-γ1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalFEBS Letters
Issue number2
Publication statusPublished - 1995 Jan 23

Bibliographical note

Funding Information:
Acknowledgments." This work was supported by Korea Research Foundation Grant (KOSEF-92-24-00-05)a nd Pohang University of Science & Technology, Pohang, Korea, 1994.

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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