Down-regulated genes in mouse dental papillae and pulp

H. Sasaki, T. Muramatsu, H. J. Kwon, H. Yamamoto, S. Hashimoto, H. S. Jung, M. Shimono

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8 Citations (Scopus)


Important factors involved in odontogenesis in mouse dental papillae disappear between the pre-and post-natal stages of development. Therefore, we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-/post-natal down-regulation. Our goal was to identify, by microarray analysis, which genes were down-regulated. Dental papillae were isolated from embryonic 16-day-, 18-day- (E16, E18), and post-natal 3-day-old (P3) murine first mandibular molar germs and analyzed by microarray. The number of down-regulated genes was 2269 between E16 and E18, and 3130 between E18 and P3. Drastic down-regulation (fold change > 10.0) of Adamts4, Aldha1a2, and Lef1 was observed at both E16 and E18, and quantitative RT-PCR revealed a post-natal reduction in their expression (Adamts4, 1/3; Aldh1a2, 1/13; and Lef1, 1/37). These results suggest that down-regulation of these three genes is an important factor in normal odontogenesis in dental papillae.

Original languageEnglish
Pages (from-to)679-683
Number of pages5
JournalJournal of Dental Research
Issue number7
Publication statusPublished - 2010 Jul

Bibliographical note

Funding Information:
This work was supported by the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid No. 17591926).

All Science Journal Classification (ASJC) codes

  • General Dentistry


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