TY - JOUR
T1 - Double-effector nanoparticles
T2 - A synergistic approach to apoptotic hyperthermia
AU - Yoo, Dongwon
AU - Jeong, Heeyeong
AU - Preihs, Christian
AU - Choi, Jin Sil
AU - Shin, Tae Hyun
AU - Sessler, Jonathan L.
AU - Cheon, Jinwoo
PY - 2012/12/7
Y1 - 2012/12/7
N2 - Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm3) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.
AB - Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm3) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.
UR - http://www.scopus.com/inward/record.url?scp=84870614898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870614898&partnerID=8YFLogxK
U2 - 10.1002/anie.201206400
DO - 10.1002/anie.201206400
M3 - Article
C2 - 23139178
AN - SCOPUS:84870614898
SN - 1433-7851
VL - 51
SP - 12482
EP - 12485
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 50
ER -
