Dose escalation using helical tomotherapy improves local control in spine metastases from primary hepatic malignancies

Yunseon Choi, Junwon Kim, Ikjae Lee, Jinsil Seong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background & Aims: This study was designed to reveal the prognostic significance of dose-escalated radiotherapy with tomotherapy in local control for spine metastases of primary hepatic tumours. Methods: From April 2006 to May 2012, 23 hepatocellular carcinoma patients and 7 intrahepatic cholangiocellular carcinoma patients (total 30 patients, 42 spinal lesions) were treated for metastatic spine lesions with helical tomotherapy (HT). The gross tumour volume (GTV) was defined as a tumour evident from computed tomography and magnetic resonance imaging. Median values were as follows: GTV total dose of 48 Gy (range 21-51), fraction size of 6 Gy (range 3-8) and eight fractions (range 3-17). Pain response was checked according to visual analogue scale (from 0 to 10). Results: The median follow-up was 5.6 months. Six events of local failure occurred, including five lesions in which spinal canals were involved at radiotherapy. Local control rate at 3 months was 86.6%. Biological equivalent dose (BED) was correlated with local control (AUC = 0.833). Higher BED (>56.0 Gy10) was associated with increased local control (P = 0.004). The median time to local progression in patients receiving ≤56.0 Gy10 and >56.0 Gy10 were 3 and 20.8 months respectively. Dose escalation (BED > 56.0 Gy10) was also associated with improved progression-free survival (median 14.7 vs. 2.8 months, P = 0.010). Pain reduction was observed in 90.9% (20/22) of patients with painful bone metastases. Conclusions: Dose-escalated radiotherapy (BED > 56.0 Gy10) using HT improved local control in spinal metastases of hepatic malignancies.

Original languageEnglish
Pages (from-to)462-468
Number of pages7
JournalLiver International
Issue number3
Publication statusPublished - 2014 Mar

All Science Journal Classification (ASJC) codes

  • Hepatology


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