Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype

Michael G. Vaughn; Kevin M. Beaver; Matt DeLisi; Matthew O. Howard; Brian E. Perron

doi:10.1016/j.alcohol.2009.02.001

Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype

Michael G. Vaughn, Kevin M. Beaver, Matt DeLisi, Matthew O. Howard, Brian E. Perron

Graduate School of Social Welfare

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Although binge drinking is a serious public health problem, relatively few studies have investigated the relationship between specific dopaminergic genes such as the dopamine D4 receptor (DRD4) and binge drinking attitudinal phenotypes. This study used the DNA subsample (N = 233, mean age 19.8, standard deviation, 0.89) of the National Longitudinal Study of Adolescent Health to investigate the association between a 48 base-pair variable number of tandem repeats in the DRD4 gene and a measure of binge drinking. Multivariate regression models indicated that the 7-repeat (7R) allele of the exon III polymorphism is significantly positively associated (β = 0.16, P < .05) with binge drinking while controlling for low self-control and demographic variables. Findings were sturdy across race and gender. The present study provides unique evidence to the genetic underpinnings of binge drinking. Results suggest that the 7R allele may be an important contributor to the liability to binge drinking.

Original language	English
Pages (from-to)	179-184
Number of pages	6
Journal	Alcohol
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.alcohol.2009.02.001
Publication status	Published - 2009 May

Bibliographical note

Funding Information:
This research uses data from Add Health, a program project designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris, and funded by a grant P01-HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development, with cooperative funding from 17 other agencies. Special acknowledgment is due to Ronald R. Rindfuss and Barbara Entwisle for assistance in the original design. Persons interested in obtaining data files from Add Health should contact Add Health, Carolina Population Center, 123 W. Franklin Street, Chapel Hill, NC 27516-2524 ( addhealth@unc.edu ). No direct support was received from grant P01-HD31921 for this analysis.

All Science Journal Classification (ASJC) codes

Health(social science)
Biochemistry
Toxicology
Neurology
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.alcohol.2009.02.001

Cite this

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title = "Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype",

abstract = "Although binge drinking is a serious public health problem, relatively few studies have investigated the relationship between specific dopaminergic genes such as the dopamine D4 receptor (DRD4) and binge drinking attitudinal phenotypes. This study used the DNA subsample (N = 233, mean age 19.8, standard deviation, 0.89) of the National Longitudinal Study of Adolescent Health to investigate the association between a 48 base-pair variable number of tandem repeats in the DRD4 gene and a measure of binge drinking. Multivariate regression models indicated that the 7-repeat (7R) allele of the exon III polymorphism is significantly positively associated (β = 0.16, P < .05) with binge drinking while controlling for low self-control and demographic variables. Findings were sturdy across race and gender. The present study provides unique evidence to the genetic underpinnings of binge drinking. Results suggest that the 7R allele may be an important contributor to the liability to binge drinking.",

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N2 - Although binge drinking is a serious public health problem, relatively few studies have investigated the relationship between specific dopaminergic genes such as the dopamine D4 receptor (DRD4) and binge drinking attitudinal phenotypes. This study used the DNA subsample (N = 233, mean age 19.8, standard deviation, 0.89) of the National Longitudinal Study of Adolescent Health to investigate the association between a 48 base-pair variable number of tandem repeats in the DRD4 gene and a measure of binge drinking. Multivariate regression models indicated that the 7-repeat (7R) allele of the exon III polymorphism is significantly positively associated (β = 0.16, P < .05) with binge drinking while controlling for low self-control and demographic variables. Findings were sturdy across race and gender. The present study provides unique evidence to the genetic underpinnings of binge drinking. Results suggest that the 7R allele may be an important contributor to the liability to binge drinking.

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Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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