Does radiotherapy for the primary tumor benefit prostate cancer patients with distant metastasis at initial diagnosis?

Yeona Cho, Jee Suk Chang, Koon Ho Rha, Sung Joon Hong, Young Deuk Choi, Won Sik Ham, Jun Won Kim, Jaeho Cho

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


Purpose/objectives: Treatment of the primary tumor reportedly improves survival in several types of metastatic cancer. We herein evaluated the efficacy and toxicity of radiotherapy for the primary tumor in prostate cancer with metastasis. Materials/methods: The study cohort included 140 men with metastatic prostate cancer at initial diagnosis. Metastatic sites were divided into 4 groups as follows: solitary bone, 2-4 bones, ≥5 bones, and visceral organs. Patient, tumor, and treatment characteristics, and clinical outcomes were compared between patients treated with (prostate radiotherapy [PRT] group) or without radiotherapy to the primary tumor. Results: Patients in PRT group presented with a statistically significantly younger age (p = .02), whereas other characteristics showed no significant difference. Overall survival (OS) and biochemical failure-free survival (BCFFS) were improved in PRT patients (3-year OS: 69% vs. 43%, p = 0.004; 3-year BCFFS: 52% vs. 16%, p = 0.002). Multivariate analysis identified PRT as a significant predictor of both OS (hazard ratio [HR] = 0.43, p = 0.015). None of the 38 PRT patients experienced severe (grade ≥3) genitourinary or gastrointestinal toxicity. Conclusions: Our data suggest that radiotherapy to the primary tumor was associated with improved OS and BCFFS in metastatic prostate cancer. The results of this study warrant prospective controlled clinical trials of this approach in stage IV prostate cancer patients with limited extent of bone metastasis and good performance status.

Original languageEnglish
Article numbere0147191
JournalPloS one
Issue number1
Publication statusPublished - 2016 Jan

Bibliographical note

Funding Information:
Funding: This work was supported by a faculty research grant from Yonsei University College of Medicine in 2014 (6-2014-0031).

Publisher Copyright:
© 2016 Cho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General


Dive into the research topics of 'Does radiotherapy for the primary tumor benefit prostate cancer patients with distant metastasis at initial diagnosis?'. Together they form a unique fingerprint.

Cite this