TY - JOUR
T1 - DNAsomes
T2 - Multifunctional DNA-based nanocarriers
AU - Roh, Young Hoon
AU - Lee, Jong Bum
AU - Kiatwuthinon, Pichamon
AU - Hartman, Mark R.
AU - Cha, Judy J.
AU - Um, Soong Ho
AU - Muller, David A.
AU - Luo, Dan
PY - 2011/1/3
Y1 - 2011/1/3
N2 - Multifunctional DNAsomes: DNA-lipid amphiphiles self-assemble into novel "DNAsomes"a-liposome-like core-shell structures with subunits composed of branched DNA-lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA-RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.
AB - Multifunctional DNAsomes: DNA-lipid amphiphiles self-assemble into novel "DNAsomes"a-liposome-like core-shell structures with subunits composed of branched DNA-lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA-RNA base-pairing, enabling efficient co-delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.
UR - http://www.scopus.com/inward/record.url?scp=78650786112&partnerID=8YFLogxK
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U2 - 10.1002/smll.201000752
DO - 10.1002/smll.201000752
M3 - Article
C2 - 21110334
AN - SCOPUS:78650786112
SN - 1613-6810
VL - 7
SP - 74
EP - 78
JO - Small
JF - Small
IS - 1
ER -