Dissimilarity of femur aging in men and women from a Nationwide Survey in Korea (KNHANES IV)

Kyoung Min Kim, Jung Soo Lim, Kwang Joon Kim, Han Seok Choi, Yumie Rhee, Han Jin Oh, Hoon Choi, Woong Hwan Choi, Jung Gu Kim, Sung Kil Lim

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


In light of the differences in hip fracture rates between men and women of different ages, age-related changes in bone structure that lead to bone fragility might differ depending on both age and gender. To investigate age-related bone loss and geometric deterioration of the femur, hip scans of 1,504 men and 2,076 women aged 19-92 years acquired during the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV) using dual-energy X-ray absorptiometry (DXA) were analyzed with a structural analysis program. Cross-sectional area and cortical thickness with bone mineral density in men started to decline from the third decade and continued to decline at a constant rate. However, in women, these parameters remained nearly constant until the fifth decade and then declined at a more rapid rate than that seen in men. Consequently, changes in the buckling ratio, earlier onset, and continuation of increase over the lifetime were observed in men. A relatively later onset with a greater acceleration with aging was observed in women. Taken together, there were obvious gender and age differences in structural trends with age. Bone aging, i.e., bone loss and geometric deterioration, actually begins at a young age, especially in men, and osteoporosis prevention strategies should target not only the elderly but also younger individuals.

Original languageEnglish
Pages (from-to)144-152
Number of pages9
JournalJournal of Bone and Mineral Metabolism
Issue number2
Publication statusPublished - 2013 Mar

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MEST) (No. 20110001024). We also express our heartfelt thanks to the Korean Osteoporosis Society.

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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