Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea

Jae Young Kim; Jae Seok Song; Song Hee Bak; Young Eun Cho; Dae Wi Kim; Seok Hoon Jeong; Yeong Min Park; Kye Joon Lee; Sang Hee Lee

doi:10.1016/j.ijantimicag.2004.03.023

Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea

Jae Young Kim, Jae Seok Song, Song Hee Bak, Young Eun Cho, Dae Wi Kim, Seok Hoon Jeong, Yeong Min Park, Kye Joon Lee, Sang Hee Lee

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Among the 51 clinical isolates collected from a university hospital in Korea, nine isolates were resistant to cephamycins. Nine isolates were shown to produce CMY-11 and these also included three isolates producing TEM-1. The results from ERIC-PCR revealed that dissemination of CMY-11 was due to outbreaks of resistant species and to the intra-species spread of resistance to cephamycins in Korea. CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. A sequence identical to the common regions in In6, In7 and a novel integron from pSAL-1 was found upstream from bla _CMY-11 gene at nucleotide 1-71. Eighteen nucleotides between position 71 and 72 were inserted into the bla _CMY-11 gene.

Original language	English
Pages (from-to)	320-326
Number of pages	7
Journal	International Journal of Antimicrobial Agents
Volume	24
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2004.03.023
Publication status	Published - 2004 Oct

Bibliographical note

Funding Information:
This work was supported by a grant from BioGreen 21 Program, Rural Development Administration, Republic of Korea.

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2004.03.023

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title = "Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea",

abstract = "Among the 51 clinical isolates collected from a university hospital in Korea, nine isolates were resistant to cephamycins. Nine isolates were shown to produce CMY-11 and these also included three isolates producing TEM-1. The results from ERIC-PCR revealed that dissemination of CMY-11 was due to outbreaks of resistant species and to the intra-species spread of resistance to cephamycins in Korea. CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. A sequence identical to the common regions in In6, In7 and a novel integron from pSAL-1 was found upstream from bla CMY-11 gene at nucleotide 1-71. Eighteen nucleotides between position 71 and 72 were inserted into the bla CMY-11 gene.",

author = "Kim, {Jae Young} and Song, {Jae Seok} and Bak, {Song Hee} and Cho, {Young Eun} and Kim, {Dae Wi} and Jeong, {Seok Hoon} and Park, {Yeong Min} and Lee, {Kye Joon} and Lee, {Sang Hee}",

note = "Funding Information: This work was supported by a grant from BioGreen 21 Program, Rural Development Administration, Republic of Korea.",

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doi = "10.1016/j.ijantimicag.2004.03.023",

language = "English",

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AU - Bak, Song Hee

AU - Cho, Young Eun

AU - Kim, Dae Wi

AU - Jeong, Seok Hoon

AU - Park, Yeong Min

AU - Lee, Kye Joon

AU - Lee, Sang Hee

N1 - Funding Information: This work was supported by a grant from BioGreen 21 Program, Rural Development Administration, Republic of Korea.

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N2 - Among the 51 clinical isolates collected from a university hospital in Korea, nine isolates were resistant to cephamycins. Nine isolates were shown to produce CMY-11 and these also included three isolates producing TEM-1. The results from ERIC-PCR revealed that dissemination of CMY-11 was due to outbreaks of resistant species and to the intra-species spread of resistance to cephamycins in Korea. CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. A sequence identical to the common regions in In6, In7 and a novel integron from pSAL-1 was found upstream from bla CMY-11 gene at nucleotide 1-71. Eighteen nucleotides between position 71 and 72 were inserted into the bla CMY-11 gene.

AB - Among the 51 clinical isolates collected from a university hospital in Korea, nine isolates were resistant to cephamycins. Nine isolates were shown to produce CMY-11 and these also included three isolates producing TEM-1. The results from ERIC-PCR revealed that dissemination of CMY-11 was due to outbreaks of resistant species and to the intra-species spread of resistance to cephamycins in Korea. CMY-11 β-lactamase genes from nine clinical isolates that were responsible for resistance to cephamycins (cefoxitin and cefotetan), amoxicillin, cephalothin and amoxicillin-clavulanic acid, were cloned and characterised. A sequence identical to the common regions in In6, In7 and a novel integron from pSAL-1 was found upstream from bla CMY-11 gene at nucleotide 1-71. Eighteen nucleotides between position 71 and 72 were inserted into the bla CMY-11 gene.

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Dissemination of Escherichia coli producing AmpC-type β-lactamase (CMY-11) in Korea

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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