Discovery of novel indazole-linked triazoles as antifungal agents

Joon Seok Park; Kyung A. Yu; Tae Hee Kang; Sunghoon Kim; Young Ger Suh

doi:10.1016/j.bmcl.2007.03.074

Discovery of novel indazole-linked triazoles as antifungal agents

Joon Seok Park, Kyung A. Yu, Tae Hee Kang, Sunghoon Kim, Young Ger Suh

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

The in vitro and in vivo activities of a series of (2R, 3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.

Original language	English
Pages (from-to)	3486-3490
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	12
DOIs	https://doi.org/10.1016/j.bmcl.2007.03.074
Publication status	Published - 2007 Jun 15

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/j.bmcl.2007.03.074

Cite this

@article{5bffbed495ce4fceaceb21d6108c94db,

title = "Discovery of novel indazole-linked triazoles as antifungal agents",

abstract = "The in vitro and in vivo activities of a series of (2R, 3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.",

author = "Park, {Joon Seok} and Yu, {Kyung A.} and Kang, {Tae Hee} and Sunghoon Kim and Suh, {Young Ger}",

year = "2007",

month = jun,

day = "15",

doi = "10.1016/j.bmcl.2007.03.074",

language = "English",

volume = "17",

pages = "3486--3490",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "12",

}

TY - JOUR

T1 - Discovery of novel indazole-linked triazoles as antifungal agents

AU - Park, Joon Seok

AU - Yu, Kyung A.

AU - Kang, Tae Hee

AU - Kim, Sunghoon

AU - Suh, Young Ger

PY - 2007/6/15

Y1 - 2007/6/15

N2 - The in vitro and in vivo activities of a series of (2R, 3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.

AB - The in vitro and in vivo activities of a series of (2R, 3R)-2-(2,4-difluorophenyl)-3-(substituted indazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol as potential antifungal agents are described. In particular, the analog 12j having 5-bromo substitution on the indazole ring exhibited significant antifungal activity against a variety of fungal cultures (Candida spp. and Aspergillus spp.). In addition, oral administration of 12j showed its excellent efficacy against Candida albicans in a murine infection model and the significantly improved survival rates of the infected mice.

UR - http://www.scopus.com/inward/record.url?scp=34249330953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249330953&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2007.03.074

DO - 10.1016/j.bmcl.2007.03.074

M3 - Article

C2 - 17433670

AN - SCOPUS:34249330953

SN - 0960-894X

VL - 17

SP - 3486

EP - 3490

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Discovery of novel indazole-linked triazoles as antifungal agents

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this