Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Vu Kim Thu; Nguyen Xuan Bach; Luu The Anh; Do Thi Trang; Nguyen Xuan Nhiem; Bui Huu Tai; Phan Van Kiem; Chau Van Minh; Seon Ju Park; Yohan Seo; Wan Namkung; Seung Hyun Kim

doi:10.1016/j.phytol.2019.07.006

Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Vu Kim Thu, Nguyen Xuan Bach, Luu The Anh, Do Thi Trang, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC₅₀ value of 22.0 ± 1.7 μM without any cytotoxicity.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	Phytochemistry Letters
Volume	33
DOIs	https://doi.org/10.1016/j.phytol.2019.07.006
Publication status	Published - 2019 Oct

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.27 , Vietnam and by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea .

Publisher Copyright:
© 2019 Phytochemical Society of Europe

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

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10.1016/j.phytol.2019.07.006

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title = "Discovery of cycloartane-type triterpene saponins from Mussaenda glabra",

abstract = "Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.",

author = "Thu, {Vu Kim} and Bach, {Nguyen Xuan} and Anh, {Luu The} and Trang, {Do Thi} and Nhiem, {Nguyen Xuan} and Tai, {Bui Huu} and {Van Kiem}, Phan and {Van Minh}, Chau and Park, {Seon Ju} and Yohan Seo and Wan Namkung and Kim, {Seung Hyun}",

note = "Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.27 , Vietnam and by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea . Publisher Copyright: {\textcopyright} 2019 Phytochemical Society of Europe",

year = "2019",

month = oct,

doi = "10.1016/j.phytol.2019.07.006",

language = "English",

volume = "33",

pages = "39--45",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier BV",

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T1 - Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

AU - Thu, Vu Kim

AU - Bach, Nguyen Xuan

AU - Anh, Luu The

AU - Trang, Do Thi

AU - Nhiem, Nguyen Xuan

AU - Tai, Bui Huu

AU - Van Kiem, Phan

AU - Van Minh, Chau

AU - Park, Seon Ju

AU - Seo, Yohan

AU - Namkung, Wan

AU - Kim, Seung Hyun

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.27 , Vietnam and by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea . Publisher Copyright: © 2019 Phytochemical Society of Europe

PY - 2019/10

Y1 - 2019/10

N2 - Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.

AB - Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.

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VL - 33

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JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Abstract

Bibliographical note

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