Discovery of cycloartane-type triterpene saponins from Mussaenda glabra

Vu Kim Thu, Nguyen Xuan Bach, Luu The Anh, Do Thi Trang, Nguyen Xuan Nhiem, Bui Huu Tai, Phan Van Kiem, Chau Van Minh, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Five new cycloartane saponins, mussaglaosides A–E (1–5) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (6–10) were isolated from the leaves of Mussaenda glabra. Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound 6 strongly inhibited chloride channel activity with IC50 value of 22.0 ± 1.7 μM without any cytotoxicity.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalPhytochemistry Letters
Publication statusPublished - 2019 Oct

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2016.27 , Vietnam and by the National Research Foundation of Korea (NRF) grant [ NRF-2016R1A2B4006742 ] funded by the Ministry of Education, Science and Technology, Republic of Korea .

Publisher Copyright:
© 2019 Phytochemical Society of Europe

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Agronomy and Crop Science
  • Plant Science


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