Discovery and synthesis of novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors

Hwan Song Jong; Gi Kim Sun; Sung No Zae; Young Lan Hyun; Ju Jeon Dong; Ikyon Kim

doi:10.5012/bkcs.2008.29.8.1467

Discovery and synthesis of novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors

Hwan Song Jong, Gi Kim Sun, Sung No Zae, Young Lan Hyun, Ju Jeon Dong, Ikyon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.

Original language	English
Pages (from-to)	1467-1471
Number of pages	5
Journal	Bulletin of the Korean Chemical Society
Volume	29
Issue number	8
DOIs	https://doi.org/10.5012/bkcs.2008.29.8.1467
Publication status	Published - 2008 Aug 20

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.5012/bkcs.2008.29.8.1467

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abstract = "The design, synthesis, and biological evaluation of structurally novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors are described. In vitro assay reveals that several compounds exhibit highly potent and selective profiles against cathepsins K or S.",

author = "Jong, {Hwan Song} and Sun, {Gi Kim} and Zae, {Sung No} and Hyun, {Young Lan} and Dong, {Ju Jeon} and Ikyon Kim",

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AU - Sun, Gi Kim

AU - Zae, Sung No

AU - Hyun, Young Lan

AU - Dong, Ju Jeon

AU - Kim, Ikyon

PY - 2008/8/20

Y1 - 2008/8/20

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Discovery and synthesis of novel N-cyanopyrazolidine and N-cyanohexahydropyridazine derivatives as cathepsin inhibitors

Abstract

All Science Journal Classification (ASJC) codes

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