Direct diversification of unmasked quinazolin-4(3: H)-ones through orthogonal reactivity modulation

Jae Bin Lee, Mi Eun Kang, Joohee Kim, Chang Young Lee, Jung Min Kee, Kyungjae Myung, Jang Ung Park, Sung You Hong

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Here we report a set of direct functionalization methods of unmasked 2-phenylquinazolin-4(3H)-ones, a privileged alkaloid core, without the installation/removal event of protecting groups or exogenous coordinating moieties. Divergent pathways were modulated with transition-metal catalysts by suppressing competitive reactivities, leading to N-arylation, annulative π-extension, or C-H fluorination.

Original languageEnglish
Pages (from-to)10394-10397
Number of pages4
JournalChemical Communications
Issue number75
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF-2016R1A2B4015497) and the IT R&D program of MOTIE/KEIT (10046306). We are grateful to Prof. R. Tenne for his helpful comments.

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


Dive into the research topics of 'Direct diversification of unmasked quinazolin-4(3: H)-ones through orthogonal reactivity modulation'. Together they form a unique fingerprint.

Cite this