TY - JOUR
T1 - Dimethylthiourea prevents MPTP-induced decrease in [3H]dopamine uptake in rat striatal slices
AU - Ji Hoe Heo, Hoe Heo
AU - Dong Goo Kim, Goo Kim
AU - Hye Ryun Bahng, Ryun Bahng
AU - Jin-Soo Kim, Kim
PY - 1995/2/13
Y1 - 1995/2/13
N2 - To determine whethr oxygen free radicals are involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, the effect of dimethylthiourea (DMTU), an effective hydroxyl radical scavenger, on MPTP-induced changes of [3H]dopamine uptake was investigated in rat striatal slices. The uptake of [3H]dopamine was decreased by MPTP treatment, and DMTU prevented the MPTP-induced decreases of [3H]dopamine uptake in a dose-dependent manner. The highest dose of DMTU used in this study completely prevented the MPTP-induced decrease of [3H]dopamine uptake. These results indicate that free radicals play a major role in the pathogenetic mechanism of MPTP-induced neurotoxicity.
AB - To determine whethr oxygen free radicals are involved in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity, the effect of dimethylthiourea (DMTU), an effective hydroxyl radical scavenger, on MPTP-induced changes of [3H]dopamine uptake was investigated in rat striatal slices. The uptake of [3H]dopamine was decreased by MPTP treatment, and DMTU prevented the MPTP-induced decreases of [3H]dopamine uptake in a dose-dependent manner. The highest dose of DMTU used in this study completely prevented the MPTP-induced decrease of [3H]dopamine uptake. These results indicate that free radicals play a major role in the pathogenetic mechanism of MPTP-induced neurotoxicity.
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U2 - 10.1016/0006-8993(94)01373-P
DO - 10.1016/0006-8993(94)01373-P
M3 - Article
C2 - 7743223
AN - SCOPUS:0028851247
SN - 0006-8993
VL - 671
SP - 321
EP - 324
JO - Brain Research
JF - Brain Research
IS - 2
ER -