Diffusion tensor imaging in patients with essential tremor

D. H. Shin, Bong Soo Han, H. S. Kim, Phil Hyu Lee

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


BACKGROUND AND PURPOSE: The traditional paradigm has regarded essential tremor (ET) as a benign disorder. However, recent clinical, neuroimaging, and neuropathologic studies suggest that ET may be a progressive neurologic disorder. Based on clinicopathologic findings that cerebellum and its outflow are the key structures in ET and degeneration of gray matter in cerebellum is followed by consequent wallerian degeneration of white matter (WM) fibers, the aim of the present study was to investigate changes in anisotropy in patients with ET. MATERIALS AND METHODS: Fractional anisotropy (FA) images were generated from DTI data acquired at 1.5T in 10 patients with ET compared with 8 control subjects by using statistical parametric mapping to make voxel-by-voxel comparisons. RESULTS: Compared with the control subjects, the patients with ET exhibited significantly reduced FA (Puncorrected < .005) in the anterolateral portion of the right pons and decreased FA in the bilateral cerebellum, left retrorubral area of the midbrain, and bilateral deep WM, including the orbitofrontal, lateral frontal, parietal, and temporal WM. CONCLUSION: This study demonstrates that structural changes in the WM are extensive in patients with ET, supporting the findings of previous functional neuroimaging and pathologic studies.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalAmerican Journal of Neuroradiology
Issue number1
Publication statusPublished - 2008 Jan

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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