Differential expression of phospholipases D1 and D2 in mouse tissues

Heechul Kim, Jeeyoung Lee, Seungjoon Kim, Min Kyoung Shin, Do Sik Min, Taekyun Shin

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


The differential expression of phospholipase D (PLD) isozymes, which include PLD1 and PLD2, was examined in various murine tissues, including the cerebrum, cerebellum, heart, lung, liver, spleen, stomach, pancreas, ileum, colon, adrenal gland, kidneys, testes, ovaries, and uterus. In Western blot analysis, only PLD1 was detected in the heart and ovary, while only PLD2 was detected in the pancreas and ileum. Both PLD1 and PLD2 were strongly expressed in the cerebrum, cerebellum, and lung, and both were also expressed in the liver, spleen, stomach, colon, kidney, testes, and uterus. Immunohistochemistry showed intense PLD immunostaining in the cerebrum, cerebellum, lungs, intestines, and testis, and weak PLD immunostaining in the liver, kidneys, spleen, and heart. These findings suggest that PLD1 and PLD2 are differentially expressed in the various organs of mice, and that each PLD isozyme plays a distinct role in each organ.

Original languageEnglish
Pages (from-to)148-155
Number of pages8
JournalCell Biology International
Issue number2
Publication statusPublished - 2007 Feb

Bibliographical note

Funding Information:
This work was supported by a program of the Basic Atomic Energy Research Institute (BAERI), which is a part of the Nuclear R & D Programs funded by the Ministry of Science & Technology (MOST) of Korea. This work was supported by Pusan National University Research Grant, 2004.

All Science Journal Classification (ASJC) codes

  • Cell Biology


Dive into the research topics of 'Differential expression of phospholipases D1 and D2 in mouse tissues'. Together they form a unique fingerprint.

Cite this