Different CXCR4 expression according to various histologic subtype of papillary thyroid carcinoma

Dong Yeob Shin; Kwang Joon Kim; Cheol Ryong Ku; Mi Kyung Lee; Soo Il Jee; Woong Youn Chung; Eun Jig Lee

doi:10.1007/s12022-013-9259-6

Different CXCR4 expression according to various histologic subtype of papillary thyroid carcinoma

Dong Yeob Shin, Kwang Joon Kim, Cheol Ryong Ku, Mi Kyung Lee, Soo Il Jee, Woong Youn Chung, Eun Jig Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0 %) than in classical PTC (50.0 %). Strong CXCR4 expression was less frequently shown in follicular variant (33.9 %) and in diffuse sclerosing variant (14.3 %) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters.

Original language	English
Pages (from-to)	169-176
Number of pages	8
Journal	Endocrine Pathology
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s12022-013-9259-6
Publication status	Published - 2013 Dec

Bibliographical note

Funding Information:
Acknowledgments This work was supported by Yonsei University College of Medicine faculty research grant 2010 (No. 6-2010-0137).

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/s12022-013-9259-6

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title = "Different CXCR4 expression according to various histologic subtype of papillary thyroid carcinoma",

abstract = "Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0 %) than in classical PTC (50.0 %). Strong CXCR4 expression was less frequently shown in follicular variant (33.9 %) and in diffuse sclerosing variant (14.3 %) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters.",

author = "Shin, {Dong Yeob} and Kim, {Kwang Joon} and Ku, {Cheol Ryong} and Lee, {Mi Kyung} and Jee, {Soo Il} and Chung, {Woong Youn} and Lee, {Eun Jig}",

note = "Funding Information: Acknowledgments This work was supported by Yonsei University College of Medicine faculty research grant 2010 (No. 6-2010-0137).",

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doi = "10.1007/s12022-013-9259-6",

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AU - Shin, Dong Yeob

AU - Kim, Kwang Joon

AU - Ku, Cheol Ryong

AU - Lee, Mi Kyung

AU - Jee, Soo Il

AU - Chung, Woong Youn

AU - Lee, Eun Jig

N1 - Funding Information: Acknowledgments This work was supported by Yonsei University College of Medicine faculty research grant 2010 (No. 6-2010-0137).

PY - 2013/12

Y1 - 2013/12

N2 - Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0 %) than in classical PTC (50.0 %). Strong CXCR4 expression was less frequently shown in follicular variant (33.9 %) and in diffuse sclerosing variant (14.3 %) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters.

AB - Functional chemokine (C-X-C motif) receptor 4 (CXCR4) is well known to be over-expressed in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate whether or not the expression of CXCR4 is different by histological subtypes of PTC and to elucidate the relationship between the expression of CXCR4 and clinicopathologic factors. CXCR4 expression in 127 PTC samples was assessed using immunohistochemical staining. The expression of CXCR4 showed different patterns according to the histological subtype of PTC (p < 0.001). A strong expression of CXCR4 was observed more frequently in the poorly differentiated region of PTC (81.0 %) than in classical PTC (50.0 %). Strong CXCR4 expression was less frequently shown in follicular variant (33.9 %) and in diffuse sclerosing variant (14.3 %) of PTC. CXCR4 expression showed a distinct pattern according to the histological subtype of PTC although not associated with other clinicopathological parameters.

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Different CXCR4 expression according to various histologic subtype of papillary thyroid carcinoma

Abstract

Bibliographical note

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UN SDGs

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