Differences in early and late mild cognitive impairment tractography using a diffusion tensor MRI

Seung Hak Lee, Jongbum Seo, Jong Min Lee, Hyunjin Park

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Diffusion tensor MRI tractography is an imaging tool that can provide information of in-vivo neuronal fiber tracts to assess progress for Alzheimer's disease (AD). In an effort to detect early AD progression, we focused on distinguishing subgroups within mild cognitive impairment (MCI): early MCI and late MCI. Tractography was applied not only to white matter regions but also neighboring gray matter regions known to be affected by AD. Nerve fibers touching the hippocampus, thalamus, and amygdala in both hemispheres were extracted to quantify limbic system fiber connectivity. Two fiber extraction algorithms, fiber assignment by continuous tracking and the Runge Kutta approach, were applied to an AD imaging database. We computed the number of fibers touching regions of interest as the imaging feature. The imaging feature could distinguish between the MCI subgroups. It was also significantly correlated with a known genetic marker for AD, the apolipoprotein E epsilon 4 allele. The number of fibers might be a useful imaging biomarker to complement conventional region of interest-based biomarkers for AD research.

Original languageEnglish
Pages (from-to)1393-1398
Number of pages6
Issue number17
Publication statusPublished - 2014 Dec 3

Bibliographical note

Publisher Copyright:
© 2014 Wolters Kluwer Health Lippincott Williams & Wilkins.

All Science Journal Classification (ASJC) codes

  • General Neuroscience


Dive into the research topics of 'Differences in early and late mild cognitive impairment tractography using a diffusion tensor MRI'. Together they form a unique fingerprint.

Cite this