Developmental and reproductive consequences of prolonged non-aging dauer in Caenorhabditis elegans

Sunhee Kim, Young Ki Paik

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


When Caenorhabditis elegans encounters harsh environmental conditions, it enters a non-aging diapause (dauer), an alternative larval stage capable of long-term survival. This replaces the stage of normal development critical for development of the reproductive organs. Here, we report that increased duration of diapause causes a delay in post-dauer development, and also causes severe defects in the reproductive development of males and hermaphrodites. Thus, the dauer state, while allowing for survival under adverse conditions, has important developmental and reproductive consequences. This effect is more pronounced in males, possibly accounting for the increased survival of C. elegans hermaphrodites in challenging environmental conditions.

Original languageEnglish
Pages (from-to)588-592
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 2008 Apr 11

Bibliographical note

Funding Information:
This work was supported by Forest Science & Technology Projects (No. S110707L0501501 to YKP) provided by Korea Forest Service, and a grant from the Basic Research Program through KOSEF (R01-2005-000-11021-0).

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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