Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter

Seung Il Yoon; Mi Hwa Lim; Se Chul Park; Jeon Soo Shin; Yone Jun Kim

Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter

Seung Il Yoon, Mi Hwa Lim, Se Chul Park, Jeon Soo Shin, Yone Jun Kim

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Citations (Scopus)

Abstract

Detection of Neisseria meningitidis, that is one of the most common causes of bacterial meningitis, is being reported, using a micromachined microcalorimeter with a split-flow microchannel structure. The split-flow microchannel scheme constantly keeps the output of the microcalorimeter near zero level when there is no biochemical reaction, which eliminates the need of an active element such as a heater. Thermal components for the microcalorimeter have been fabricated on a high thermal resistivity layer to improve the sensitivity of the device. Using the fabricated sensor, a biological reaction between Neisseria meningitidis group B (NMGB) and a specific monoclonal antibody to its capsular polysaccharide was detected. In order to verify the reliability of the measurement, exactly same number of NMGB was reacted with HmenB3, and optical density was measured by ELISA.

Original language	English
Title of host publication	Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007
Pages	509-512
Number of pages	4
Publication status	Published - 2007
Event	20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007 - Kobe, Japan Duration: 2007 Jan 21 → 2007 Jan 25

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Other

Other	20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007
Country/Territory	Japan
City	Kobe
Period	07/1/21 → 07/1/25

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Cite this

Yoon, S. I., Lim, M. H., Park, S. C., Shin, J. S., & Kim, Y. J. (2007). Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. In Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007 (pp. 509-512). Article 4433116 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Yoon, Seung Il ; Lim, Mi Hwa ; Park, Se Chul et al. / Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. pp. 509-512 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter",

abstract = "Detection of Neisseria meningitidis, that is one of the most common causes of bacterial meningitis, is being reported, using a micromachined microcalorimeter with a split-flow microchannel structure. The split-flow microchannel scheme constantly keeps the output of the microcalorimeter near zero level when there is no biochemical reaction, which eliminates the need of an active element such as a heater. Thermal components for the microcalorimeter have been fabricated on a high thermal resistivity layer to improve the sensitivity of the device. Using the fabricated sensor, a biological reaction between Neisseria meningitidis group B (NMGB) and a specific monoclonal antibody to its capsular polysaccharide was detected. In order to verify the reliability of the measurement, exactly same number of NMGB was reacted with HmenB3, and optical density was measured by ELISA.",

author = "Yoon, {Seung Il} and Lim, {Mi Hwa} and Park, {Se Chul} and Shin, {Jeon Soo} and Kim, {Yone Jun}",

year = "2007",

language = "English",

isbn = "1424409519",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

pages = "509--512",

booktitle = "Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007",

note = "20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007 ; Conference date: 21-01-2007 Through 25-01-2007",

}

Yoon, SI, Lim, MH, Park, SC, Shin, JS & Kim, YJ 2007, Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. in Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007., 4433116, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), pp. 509-512, 20th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2007, Kobe, Japan, 07/1/21.

Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. / Yoon, Seung Il; Lim, Mi Hwa; Park, Se Chul et al.
Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. p. 509-512 4433116 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter

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AB - Detection of Neisseria meningitidis, that is one of the most common causes of bacterial meningitis, is being reported, using a micromachined microcalorimeter with a split-flow microchannel structure. The split-flow microchannel scheme constantly keeps the output of the microcalorimeter near zero level when there is no biochemical reaction, which eliminates the need of an active element such as a heater. Thermal components for the microcalorimeter have been fabricated on a high thermal resistivity layer to improve the sensitivity of the device. Using the fabricated sensor, a biological reaction between Neisseria meningitidis group B (NMGB) and a specific monoclonal antibody to its capsular polysaccharide was detected. In order to verify the reliability of the measurement, exactly same number of NMGB was reacted with HmenB3, and optical density was measured by ELISA.

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T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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Yoon SI, Lim MH, Park SC, Shin JS, Kim YJ. Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter. In Proceedings - CIS Workshops 2007, 2007 International Conference on Computational Intelligence and Security Workshops, CISW 2007. 2007. p. 509-512. 4433116. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Detection of Neisseria meningitidis using a micromachined split-flow microcalorimeter

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All Science Journal Classification (ASJC) codes

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