Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics

Juwon Kim; Tae Sung Park; Jaewoo Song; Kyung A. Lee; Duk Jin Hong; Yoo Hong Min; June Won Cheong; Jong Rak Choi

doi:10.1016/j.cancergencyto.2009.06.010

Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics

Juwon Kim, Tae Sung Park, Jaewoo Song, Kyung A. Lee, Duk Jin Hong, Yoo Hong Min, June Won Cheong, Jong Rak Choi

Department of Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

Original language	English
Pages (from-to)	111-118
Number of pages	8
Journal	Cancer genetics and cytogenetics
Volume	194
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2009.06.010
Publication status	Published - 2009 Oct 15

All Science Journal Classification (ASJC) codes

Molecular Biology
Genetics
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cancergencyto.2009.06.010

Cite this

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title = "Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics",

abstract = "Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.",

author = "Juwon Kim and Park, {Tae Sung} and Jaewoo Song and Lee, {Kyung A.} and Hong, {Duk Jin} and Min, {Yoo Hong} and Cheong, {June Won} and Choi, {Jong Rak}",

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AU - Kim, Juwon

AU - Park, Tae Sung

AU - Song, Jaewoo

AU - Lee, Kyung A.

AU - Hong, Duk Jin

AU - Min, Yoo Hong

AU - Cheong, June Won

AU - Choi, Jong Rak

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Y1 - 2009/10/15

N2 - Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

AB - Reciprocal t(16;21)(p11;q22) is a rare chromosomal abnormality in acute myeloid leukemia (AML). The chimeric transcript FUS-ERG formed by this translocation which causes the replacement of RNA-binding domain of FUS (alias TLS) with the DNA-binding domain of ERG, and this event is thought to be responsible for leukemogenesis. Here we report two cases of AML with t(16;21)(p11.2;q22) showing unusual characteristics, and address the clinical, hematological, and molecular aspects of leukemia with t(16;21), along with a review of the literature.

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Detection of FUS-ERG chimeric transcript in two cases of acute myeloid leukemia with t(16;21)(p11.2;q22) with unusual characteristics

Abstract

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