Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors

Farhanullah, Su Yeon Kim, Eun Jeong Yoon, Eung Chil Choi, Sunghoon Kim, Taehee Kang, Farhana Samrin, Sadhna Puri, Jeewoo Lee

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.

Original languageEnglish
Pages (from-to)7154-7159
Number of pages6
JournalBioorganic and Medicinal Chemistry
Issue number21
Publication statusPublished - 2006 Nov 1

Bibliographical note

Funding Information:
This work was supported by a Grant (03-PJ2-PG4-BD02-0001) from the Ministry of Health and Welfare, R.O.K.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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