Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Cheol Kyu Han; Soon Kil Ahn; Nam Song Choi; Ryung Kee Hong; Seung Kee Moon; Hyoung Sik Chun; Sang Joon Lee; Jung Woo Kim; Chung Il Hong; Deukjoon Kim; Jeong Hyeok Yoon; Kyoung Tai No

doi:10.1016/S0960-894X(99)00577-6

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Cheol Kyu Han, Soon Kil Ahn, Nam Song Choi, Ryung Kee Hong, Seung Kee Moon, Hyoung Sik Chun, Sang Joon Lee, Jung Woo Kim, Chung Il Hong, Deukjoon Kim, Jeong Hyeok Yoon, Kyoung Tai No

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.

Original language	English
Pages (from-to)	39-43
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/S0960-894X(99)00577-6
Publication status	Published - 2000 Jan 3

Bibliographical note

Funding Information:
We acknowledge financial support from the Ministry of Health and Welfare (HMP-98-D-4-0027). Dr. K. T. No thanks the Basic Science Research Institute Program of the Ministry of Education (BSRI-96-3448) for research grants.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.",

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note = "Funding Information: We acknowledge financial support from the Ministry of Health and Welfare (HMP-98-D-4-0027). Dr. K. T. No thanks the Basic Science Research Institute Program of the Ministry of Education (BSRI-96-3448) for research grants.",

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doi = "10.1016/S0960-894X(99)00577-6",

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AU - Ahn, Soon Kil

AU - Choi, Nam Song

AU - Hong, Ryung Kee

AU - Moon, Seung Kee

AU - Chun, Hyoung Sik

AU - Lee, Sang Joon

AU - Kim, Jung Woo

AU - Hong, Chung Il

AU - Kim, Deukjoon

AU - Yoon, Jeong Hyeok

AU - No, Kyoung Tai

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PY - 2000/1/3

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Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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