Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties

Kyung Mi Kim; Kyung Hwa Kim; Tae Cheon Kang; Won Yeon Kim; Myung Ryul Lee; Hyuk Jun Jung; In Koo Hwang; Sung Bo Ko; Jae Young Koh; Moo Ho Won; Eu Gene Oh; Injae Shin

doi:10.1016/S0960-894X(03)00444-X

Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties

Kyung Mi Kim, Kyung Hwa Kim, Tae Cheon Kang, Won Yeon Kim, Myung Ryul Lee, Hyuk Jun Jung, In Koo Hwang, Sung Bo Ko, Jae Young Koh, Moo Ho Won, Eu Gene Oh, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.

Original language	English
Pages (from-to)	2273-2275
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(03)00444-X
Publication status	Published - 2003 Jul 21

Bibliographical note

Funding Information:
This work (IS) was supported by a grant of the Ministry of Health and Welfare (02-PJ2-PG3-21503-0008).

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(03)00444-X

Cite this

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title = "Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties",

abstract = "In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.",

author = "Kim, {Kyung Mi} and Kim, {Kyung Hwa} and Kang, {Tae Cheon} and Kim, {Won Yeon} and Lee, {Myung Ryul} and Jung, {Hyuk Jun} and Hwang, {In Koo} and Ko, {Sung Bo} and Koh, {Jae Young} and Won, {Moo Ho} and Oh, {Eu Gene} and Injae Shin",

note = "Funding Information: This work (IS) was supported by a grant of the Ministry of Health and Welfare (02-PJ2-PG3-21503-0008).",

year = "2003",

month = jul,

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doi = "10.1016/S0960-894X(03)00444-X",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties

AU - Kim, Kyung Mi

AU - Kim, Kyung Hwa

AU - Kang, Tae Cheon

AU - Kim, Won Yeon

AU - Lee, Myung Ryul

AU - Jung, Hyuk Jun

AU - Hwang, In Koo

AU - Ko, Sung Bo

AU - Koh, Jae Young

AU - Won, Moo Ho

AU - Oh, Eu Gene

AU - Shin, Injae

N1 - Funding Information: This work (IS) was supported by a grant of the Ministry of Health and Welfare (02-PJ2-PG3-21503-0008).

PY - 2003/7/21

Y1 - 2003/7/21

N2 - In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.

AB - In order to develop therapeutic agents against neurodegenerative diseases, we designed novel antioxidants containing N-t-butyl-N-hydroxylaminophenyl moieties and evaluated in vitro and in vivo neuroprotective properties as well as anti-ischemic effects.

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EP - 2275

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Design and biological evaluation of novel antioxidants containing N-t-Butyl-N-hydroxylaminophenyl moieties

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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