Derivation of YCMi005-A, a human-induced pluripotent stem cell line, from a patient with dilated cardiomyopathy carrying missense variant in TPM1 (p. Glu192Lys)

Yun Ji Cha, Sae Bom Jeon, Jaewon Oh, Seung Tae Lee, Sangwoo Kim, Hyoeun Kim, Jungyoon Choi, Hyo Kyoung Choi, Dongju Won, Jong Rak Choi, Seok Jun Kim, Sahng Wook Park, Seok Min Kang, Seung Hyun Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.

Original languageEnglish
Article number102707
JournalStem Cell Research
Volume60
DOIs
Publication statusPublished - 2022 Apr

Bibliographical note

Publisher Copyright:
© 2022 The Author(s)

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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