Abstract
Dendritic nanomaterials have attracted a great deal of scientific interest for use in various biomedical applications primarily due to their well-defined structure and capacity for multifunctionalization. In this chapter, we present a comprehensive overview of the recent advances in various dendrimers and their modified dendritic materials with a particular focus on their applications such as drug delivery, gene delivery, diagnostics and prognostics, and detoxification/ prophylaxis. We also discuss the fundamentals of the biological interactions of dendritic nanomaterials in regard to non-specific cell interactions, multivalent binding, stimuli-responsive processes, and biodistribution. In addition, this chapter highlights the current drawbacks of dendrimers that have hindered their rapid clinical translation and introduce recent approaches to overcoming these challenges.
| Original language | English |
|---|---|
| Title of host publication | Biomedical Engineering |
| Subtitle of host publication | Frontier Research and Converging Technologies |
| Publisher | Springer International Publishing |
| Pages | 41-75 |
| Number of pages | 35 |
| Volume | 9 |
| ISBN (Electronic) | 9783319218137 |
| ISBN (Print) | 9783319218120 |
| DOIs | |
| Publication status | Published - 2015 Jul 23 |
Bibliographical note
Publisher Copyright:© Springer International Publishing Switzerland 2016. All rights are reserved.
All Science Journal Classification (ASJC) codes
- Engineering(all)
- Medicine(all)
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)