Dendritic Nanocarrier Platforms for Gene and Drug Delivery Applications

Hong Y. Cho, Jason Bugno, Seungpyo Hong

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dendrimers are a unique class of polymers possessing three-dimensional, chemically well-defined, hyperbranched architecture, along with conformational flexibility and high surface area topology. These characteristic features, as well as their modularity-by precisely controlling their nanoscale size and surface functional groups, distinguish them from conventional linear polymers and make them well suited for a variety of biomedical applications. In this chapter, we highlight the synthetic routes and recent biomedical applications of several representative dendrimers and dendritic nanoparticles, with a focus on their use in targeted drug and gene delivery. In addition, we also discuss recently reported hybridization approaches that integrate dendritic polymers with other types of polymers in an effort to overcome current hurdles that have hindered the rapid clinical translation of dendritic polymers.

Original languageEnglish
Title of host publicationPerspectives in Micro- and Nanotechnology for Biomedical Applications
PublisherWorld Scientific Publishing Co.
Pages85-124
Number of pages40
ISBN (Electronic)9781783269617
ISBN (Print)9781783269600
DOIs
Publication statusPublished - 2016 Jan 1

Bibliographical note

Publisher Copyright:
© 2016 by Imperial College Press.

All Science Journal Classification (ASJC) codes

  • General Engineering
  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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