Dendrimer-mediated multivalent binding for the enhanced capture of tumor cells

Ja Hye Myung; Khyati A. Gajjar; Jelena Saric; David T. Eddington; Seungpyo Hong

doi:10.1002/anie.201105508

Dendrimer-mediated multivalent binding for the enhanced capture of tumor cells

Ja Hye Myung, Khyati A. Gajjar, Jelena Saric, David T. Eddington, Seungpyo Hong

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

139 Citations (Scopus)

Abstract

A naturally occurring multivalent binding effect is manipulated by engineering cell capture surfaces using dendrimers. The enhanced binding through the multivalent effect significantly improves detection of tumor cells. This improvement can be potentially translated into clinically significant detection of circulating tumor cells from the blood of cancer patients.

Original language	English
Pages (from-to)	11769-11772
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	49
DOIs	https://doi.org/10.1002/anie.201105508
Publication status	Published - 2011 Dec 2

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.201105508

Cite this

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abstract = "A naturally occurring multivalent binding effect is manipulated by engineering cell capture surfaces using dendrimers. The enhanced binding through the multivalent effect significantly improves detection of tumor cells. This improvement can be potentially translated into clinically significant detection of circulating tumor cells from the blood of cancer patients.",

author = "Myung, {Ja Hye} and Gajjar, {Khyati A.} and Jelena Saric and Eddington, {David T.} and Seungpyo Hong",

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AU - Hong, Seungpyo

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Dendrimer-mediated multivalent binding for the enhanced capture of tumor cells

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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