Delayed recurrence of atrial fibrillation 2 years after catheter ablation is associated with metabolic syndrome

Yong Soo Baek, Pil Sung Yang, Tae Hoon Kim, Jae Sun Uhm, Jong Youn Kim, Boyoung Joung, Moon Hyoung Lee, Hui Nam Pak

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15 Citations (Scopus)


Background Whether delayed clinical recurrence of atrial fibrillation (AF) 2 years after radiofrequency catheter ablation (CR> 2-years) is related to AF progression remains unclear. Objective We hypothesized that metabolic factors are associated with CL> 2-years. Methods Among 1825 patients who underwent catheter ablation, the study included 523 patients with AF recurrence (27.2% women, mean age 57 ± 11 years, 58.3% paroxysmal AF) 3 months after the ablation procedure. They were divided into the clinical recurrence within 2-years (CL≤ 2-years: AF recurrence at 3–24 months) and CL> 2-years (AF recurrence > 24 months) groups. Clinical and imaging parameters and polysomnograms were compared. Results Over 42 ± 19 months of follow-up, 409 (78.2%) and 114 (21.8%) patients formed the CL≤ 2-years and CL> 2-years groups, respectively. The CL> 2-years group had higher proportions of overweight (p = 0.004), hypertension (p = 0.049), diabetes mellitus (p = 0.037), dyslipidemia (p = 0.009), high sensitivity C-reactive protein > 8 mg/L (p = 0.049), and metabolic syndrome (p = 0.011) than the CL≤ 2-years group. Despite no significant difference between the apnea and hypopnea indices in the CL≤ 2-years (n = 97) and CL> 2-years (n = 28) groups, the minimum peripheral oxygen saturation was significantly lower in the latter than the former (p = 0.032). In the multivariate analysis, overweight (odds ratio [OR] 1.756, 95% confidence interval [CI] 1.146–2.693, p = 0.010), dyslipidemia (OR 1.587, 95% CI 1.033–2.438, p = 0.035), and metabolic syndrome (OR 1.972, 95% CI 1.158–3.356, p = 0.012) were independently associated with CL> 2-years. Conclusions Overweight, dyslipidemia, and metabolic syndrome are independent predictors of CL> 2-years for AF after catheter ablation. CL> 2-years seems to be affected by metabolic factors and can be related to AF progression.

Original languageEnglish
Pages (from-to)276-281
Number of pages6
JournalInternational Journal of Cardiology
Publication statusPublished - 2016 Nov 15

Bibliographical note

Funding Information:
This work was supported by a grant ( A085136 ) from the Korea Health 21 R&D Project, Ministry of Health and Welfare , and a grant ( NRF-2013R1A2A2A01014634 ) from the Basic Science Research Program run by the National Research Foundation of Korea (NRF) , which is funded by the Ministry of Science, ICT, & Future Planning (MSIP) .

Publisher Copyright:
© 2016 Elsevier Ireland Ltd

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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